Bautista Ezcurra will make his Argentina debut in Saturday’s Test against Scotland in Resistencia.
The 23-year-old’s selection ahead of Jeronimo de la Fuente at inside centre is one of six changes made by Pumas head coach Daniel Hourcade, who will step down after the game.
The other backline alteration sees winger Sebastian Cancelliere start in place of the injured Ramiro Moyano as Argentina look to respond following their back-to-back defeats to Wales.
Tomas Lezana and veteran Leonardo Senatore come into the back row, Matias Alemanno starts at lock and Javier Diaz replaces Santiago Garcia Botta at loosehead prop.
Scotland have made eight changes to the team that suffered a surprise loss to the United States last weekend with captain Stuart McInally making his first appearance of their summer tour.
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Argentina: 15 Emiliano Boffelli, 14 Bautista Delguy, 13 Matias Orlando, 12 Bautista Ezcurra, 11 Sebastian Cancelliere, 10 Nicolas Sanchez, 9 Martín Landajo; 1 Javier Diaz, 2 Agustin Creevy (c), 3 Nahuel Tetaz Chaparro, 4 Guido Petti, 5 Matias Alemanno, 6 Pablo Matera, 7 Tomas Lezana, 8 Leonardo Senatore.
Replacements: 16 Julian Montoya, 17 Santiago Garcia Botta, 18 Santiago Medrano, 19 Marcos Kremer, 20 Tomas Lavanini, 21 Gonzalo Bertranou, 22 Santiago Gonzalez Iglesias, 23 Juan Cruz Mallia.