O prémio Screen Actors Guild Award para Melhor Ator (principal) em cinema é dado pelo sindicato americano Screen Actors Guild para honrar as melhores interpretações de atores (masculinos) no cinema num papel principal.
1994: Tom Hanks - Forrest Gump
1995: Nicolas Cage - Leaving Las Vegas
1997: Jack Nicholson - As Good as it Gets
1998: Roberto Benigni - Life is Beautiful (a.k.a. La Vita è Bella)
1999: Kevin Spacey - American Beauty
2000: Russell Crowe - Gladiator
2001: Russell Crowe - A Beautiful Mind
2002: Daniel Day-Lewis - Gangs of New York
2003: Johnny Depp - Pirates of the Caribbean: The Curse of the Black Pearl
2004: Jamie Foxx - Ray
2005: Philip Seymour Hoffman - Capote
Tom Hanks (1994) · Nicolas Cage (1995) · Geoffrey Rush (1996) · Jack Nicholson (1997) · Roberto Benigni (1998) · Kevin Spacey (1999) · Benicio del Toro (2000)
Russell Crowe (2001) · Daniel Day-Lewis (2002) · Johnny Depp (2003) · Jamie Foxx (2004) · Philip Seymour Hoffman (2005) · Forest Whitaker (2006) · Daniel Day-Lewis (2007) · Sean Penn (2008) · Jeff Bridges (2009) · Colin Firth (2010) · Jean Dujardin (2011)